And here is the other FACTM pt 1 teaching unit you may have missed last Tuesday. It deals with Schistosoma species; the group of blood flukes that cause a range of clinical syndromes including swimmer’s itch, Katayama fever and urinary schistosomiasis. You can find additional information on the Priobe Net.
Anton Breinl Centre, James Cook University, Townsville, QLD, 11th June, 2010
- Introduction to arbovirus infections. Tim Inglis
- Helminth infections. Richard Bradbury
- Trypanosomiasis in Australia. Rick Speare
- Rickettsial Diseases. Steven Graves
- Travel-related diarrhoeal disease. Sanatu Chatterjee
Introduction to arbovirus infections [full lecture here]
Helminth infections. R Bradbury, University of Tasmania
Helminths infections have been evident since early recorded history.
- adult male previously resident overseas, with Fascioliasis
- adult male from Darwin with Paragonimiasis
- adult refugee ex Africa with Schistosomiasis
- child in Mauritius with Bartiella
- elderly adult from Hobart with cutaneous larva migrans
- adult from Tasmania with Haycocknema myositis
Trypanosomiasis in Australia. R Speare, James Cook University
So far there have been only 4 cases of Trypanosomiasis reported in Australia, but the number is likely to increase due to the arrival of African refugees and increased travel by Australians to African game parks. There are key differences between East and West African Trypanosomiasis in the course of infection, tests used and most effective treatment. However, available laboratory tests are insensitive and all drugs used to treat Trypanosomiasis are toxic. The overlapping geographic distribution of East and West African Trypanosomiasis in Uganda will increase the diagnostic challenge. South African Trypanosomiasis or Chagas’ disease has a different clinical presentation and treatment.
Rickettsial Diseases, S Graves, Hunter Valley, NSW.
There are four groups of diseases caused by the small, obligate Gram negative bacteria that make up the rickettsias. These are Q fever, the spotted fever group, the typhus group and scrub typhus. The key step in arriving at a diagnosis of one of these diseases is to think of rickettsias in the first place. Epidemiological clues include working in an abattoir, going on safari in Africa, or bush walking. Some but not all patients may have an eschar. Lab investigations need to be done in a centre with rickettsial expertise and include nucleic acid assays (PCR) or serology. PCR is better during the initial stage of an acute infection, while serology is better after time has passed to develop an antibody response. Micro-immunofluorescence is considered a reference standard serological method.
Traveller’s diarrhoea. S Chatterjee, Kolkota, India
There are an estimated 80,000 cases of traveller’s diarrhoea per day and the condition is top of the travel-associated risks list. However, expatriate residents have almost the same rate of diarrhoeal disease as local people. If a thorough laboratory investigation is conducted, 80% will have a pathogen identified. Almost all international travellers make a food or drink mistake in the first 72 hours of a trip. Common causes are faecal contamination of food, water and drinks, or poorly cooked seafood. In India the attack rate is more than 50%. Antibiotic use for TD is being re-evaluated. Co-trimoxazole and doxycycline are largely obsolete. Bismuth and probiotics appear to be ineffective. Ciprofloxacin works in the majority of cases. Rifamaxin is under active consideration. However 55% cases will resolve spontaneously. On prevention, oral cholera vaccine is useful and has added benefit of prevention of toxogenic E.coli infection.
Our next Tropical Medicine Breakfast is coming up fast. We’re going to be taking a look at two very different infections associated with travel in tropical places: rabies and schistosomiasis. For those studying for the part 1 FACTM exam, a short reading list will appear on this site before the weekend. Event calendar.
Snake bite. Prof D Warrell, University of Oxford
Snake bite is one of the most neglected of tropical diseases. Its victims often die before admission to hospital and are thus lost from statistical analyses. A study from Bangladesh reported an estimate 700,000 bites per year causing 6000 fatalities. In India where the offical figure is 14,000 deaths from snake bite over many years, the estimated annual fatality figure has been estimated at over 45,000. Recent methods of analysis have applied a verbal autopsy to obtain more accurate data. Current figures are therefore likely to underestimate the global impact.
The burden of disease caused by snake bite is being reduced by a combination of approaches:
- minimising contact with snakes through behaviour modification & appropriate clothing
- improved first aid measures
- better medical management
There has been a substantial Australian contribution in several areas:
1 description of the Australian herpetofauna. Some are amongst the most venomous known. A new species of Taipan was recently discovered and named Oxyuranus frontalis, distinguished by a subtle difference in the arrangement of head scales, requiring examination at close quarters.
2 antivenom development. First use of antivenom was by Albert Calmette of the Institut Pasteur in Saigon, in 1894. He successfully used a specific antivenom raised against the monacled cobra venom to treat a laboratory worker who had been accidentally exposed. However, subsequent experience showed that this antivenom was too specific to use for all snake bites. In 1902 Tidswell described a tiger snake antivenom. Tiger snake bite has a fatality rate of up to 85%.
3 understanding the action & evolution of snake venom. Snake venoms are highly specialised in their action and have considerable specificity. They include a muscle damaging phospholipase, group C and D prothombin activators and naturietic peptides. The ACE inhibitor captopril was developed from the venom of the Brazilian jararaca snake.
4 development of effective first aid methods. Hamilton-Fairley recognised that snake venoms were rapidly absorbed via the lymphatics and that ligatures worked only as long as they were applied. However, some venoms are partly inactivated during this period. The pressure immobilisation method was described by Sutherland in 1979 and is now widely used. There are anecdotal descriptions of deterioration after release of the pressure bandage, but there has been no prospective RCT or other formal trials of clinical efficacy. The PIM approach is difficult to teach well, apply consistently and maintain, especially during transport to hospital. Alterntive methods e.g. the Monash foam rubber pad, may be more widely applicable at lower cost and with less prior expertise.
Before the colonial era Australia’s indigenous peoples had learned to live with some of the most dangerous snakes in the world. Data are hard to come by and suggest a currently variable experience of snake bite in indigenous communities from never recorded to a leading cause of death. Locally, the Banjan people introduce their children to the issue through dramatic instruction by wise people, or gubi murrays. They are taught to respect snakes, to walk in single file, to know places and times where snakes will be, and to burn off the area around a campsite. Snake bite is seen as a punishment for breaking the adult code. There have been no cases of snake bite or subsequent death in recent times (oral account, Russell Butler).